专论与研究

水稻胚乳细胞生物反应器研究进展

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  • 浙江大学应用生物科学系,杭州 310029

网络出版日期: 2017-05-20

基金资助

转基因专项(2014ZX08001006);浙江省水稻育种(2016C02050-6)

Progress on Rice Endosperm Cells as a Bioreactor

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Online published: 2017-05-20

摘要

水稻胚乳细胞生物反应器是一种理想的生物活性物质生产工厂,本文综述了以水稻胚乳细胞为生物反应器生产药物蛋白、疫苗、功能肽及非蛋白类生物活性物质的研究进展。

本文引用格式

丁一,魏际华,张宁*,舒小丽,吴殿星 . 水稻胚乳细胞生物反应器研究进展[J]. 中国稻米, 2017 , 23(3) : 6 -12 . DOI: 10.3969/j.issn.1006-8082.2017.03.002

Abstract

Rice endosperm cell is one of the ideal bioreactor for the production of bio-active substances. Research progresses on production of pharmaceutical protein, vaccine, functional peptide and non-protein bio-active substances using rice endosperm as bioreactor were reviewed in this paper.

参考文献

[1] 张胜利,李东方,许桂芳,等. 植物生物反应器在生物制药中的应用[J]. 资源开发与市场,2011,27(2):102-105. [2] 杨晶,李天航,熊丽东,等. 植物生物反应器的研究进展[J]. 生物工程学报,2009,25(5):650-657. [3] 杜小春,何正权,陈磊,等. 植物生物反应器表达药用蛋白研究新进展[J]. 中国生物工程杂志,2008,2(9):135-143. [4] 仇晴川,杨代常. 分子医药农业研究进展[J]. 武汉植物学研究,2009,7(1):83-89. [5] Luo J, Ning T, Sun Y, et al. Proteomic analysis of rice endosperm cells in response to expression of hGM-CSF[J]. J Proteome Res, 2008, 8(2): 829-837. [6] Ning T, Xie T, Qiu Q, et al. Oral administration of recombinant human granulocyte-macrophage colony stimulating factor expressed in rice endosperm can increase leukocytes in mice[J]. Biotechnol Lett, 2008, 30(9): 1679-1686. [7] Sardana R, Dudani A K, Tackaberry E, et al. Biologically active human GM-CSF produced in the seeds of transgenic rice plants[J]. Transgenic Res, 2007, 16(6): 713-721. [8] Xie T, Qiu Q, Zhang W, et al. A biologically active rhIGF-1 fusion accumulated in transgenic rice seeds can reduce blood glucose in diabetic mice via oral delivery[J]. Peptides, 2008, 29(11): 1 862 - 1 870. [9] He Y, Ning T, Xie T, et al. Large-scale production of functional human serum albumin from transgenic rice seeds[J]. Proc Nat Acad Sci USA, 2011, 108(47): 19 078-19 083. [10] Chen Z, He Y, Shi B, et al. Human serum albumin from recombinant DNA technology: challenges and strategies[J]. Biochim Biophys Acta, 2013, 1830(12): 5 515 - 5 525. [11] Yang D, He Y, Li G, et al. Method for isolating and purifying recombinant human serum albumin from transgenic rice grain[P]. United States Patent Application, 20120165509, 2015. [12] Zhang L, Shi J, Jiang D, et al. Expression and characterization of recombinant human alpha-antitrypsin in transgenic rice seed[J]. J Biotechnol, 2013, 164(2): 300-308. [13] An N, Ou J, Jiang D, et al. Expression of a functional recombinant human basic fibroblast growth factor from transgenic rice seeds[J]. Int J Mol Sci, 2013, 14(2): 3 556 - 3 567. [14] Huang J, Nandi S, Wu L, et al. Expression of natural antimicrobial human lysozyme in rice grains[J]. Mol Breed, 2002, 10(1): 83-94. [15] Nandi S, Yalda D, Lu S, et al. Process development and economic evaluation of recombinant human lactoferrin expressed in rice grain[J]. Transgenic Res, 1995, 66(14): 237-249. [16] Kim T G, Baek M Y, Lee E K, et al. Expression of human growth hormone in transgenic rice cell suspension culture[J]. Plant Cell Rep, 2008, 27(5): 885-891. [17] Yasuda H, Tada Y, Hayashi Y, et al. Expression of the Small Peptide GLP-1 in Transgenic Plants[J]. Transgenic Res, 2005, 14(5): 677-684. [18] Fujiwara Y, Aiki Y, Yang L, et al. Extraction and purification of human interleukin-10 from transgenic rice seeds[J]. Protein Expr Purif, 2010, 72(1): 125-130. [19] Yang L, S H, Takahashi H, et al. Recombinant protein yield in rice seed is enhanced by specific suppression of endogenous seed proteins at the same deposit site[J]. Plant Biotechnol J, 2012, 10(9): 1 035-1 045. [20] Kudo K, Ohta M, Yang L, et al. ER stress response induced by the production of human IL-7 in rice endosperm cells[J]. Plant Mol Biol, 2013, 81(4): 461-475. [21] Fujiwara Y, Yang L, Takaiwa F, et al. Expression and purification of recombinant mouse interleukin-4 and -6 from transgenic rice seeds[J]. Mol Biotechnol, 2016, 58(4): 1-9. [22] Jung J W, Kim N S, Jang S H, et al. Production and characterization of recombinant human acid α-glucosidase in transgenic rice cell suspension culture[J]. J Biotechnol, 2016, 226: 44-53. [23] Matsumoto Y, Suzuki S, Nozoye T, et al. Oral immunogenicity and protective efficacy in mice of transgenic rice plants producing a vaccine candidate antigen (As16) of Ascaris suum fused with cholera toxin B subunit[J]. Transgenic Res, 2009, 18(2): 185-192. [24] Tokuhara D, Suzuki S, Nozoye T, et al. Oral immunogenicity and protective efficacy in mice of transgenic rotavirus infection[J]. J Clini Invest, 2013,123(9): 3 829-3 838. [25] Taiji Yoshida, Eiichi Kimura1, Setsuo Koike, et al. Transgenic rice expressing amyloid β-peptide for oral immunization [J]. Int J Biol Sci, 2011,7(3):301-307. [26] Yang L, Kajiura H, Suzuki K,et al. Generation of a transgenic rice seed-based edible vaccine against house dust mite allergy[J]. Biochem Biophys Res Commun, 2008, 365(2): 334-339. [27] Suzuki K, Kaminuma O, Yang L, et al. Prevention of allergic asthma by vaccination with transgenic rice seed expressing mite allergen: induction of allergen-specific oral tolerance without bystander suppression[J]. Plant Biotechnol J, 2011, 9(9): 982-990. [28] Gu Q, Ning H, Liu J, et al. Expression of Helicobacter pylori urease subunit B gene in transgenic rice[J]. Biotechnol Lett, 2006, 28(20): 1 661-1 666. [29] Yuki Y, Mejima M, Kurokawa S, et al. Induction of toxin-specific neutralizing immunity by molecularly uniform rice-based oral cholera toxin B subunit vaccine without plant-associated sugar modification[J]. Plant Biotechnol J, 2013, 11(7):799-808. [30] Kashima K, Yuki Y, Mejima M, et al. Good manufacturing practices production of a purification-free oral cholera vaccine expressed in transgenic rice plants[J]. Plant Cell Rep, 2016, 35(3): 1-13. [31] Soh H S, Chung H Y, Lee H H, et al. Expression and functional validation of heat-labile enterotoxin B (LTB) and cholera toxin B (CTB) subunits in transgenic rice (Oryza sativa )[J]. SpringerPlus, 2015, 4(1): 1-14. [32] Takagi H, Saito S, Yang L, et al. Oral immunotherapy against a pollen allergy using a seed-based peptide vaccine[J]. Plant Biotechnol J, 2005, 3(5): 521-533. [33] Takaiwa F, Yang L, Maruyama N, et al. Deposition mode of transforming growth factor-β expressed in transgenic rice seed[J]. Plant Cell Rep, 2016, 1-13. [34] Wakasa Y, Zhao H, Hirose S, et al. Antihypertensive activity of transgenic rice seed containing an 18-repeat novokinin peptide localized in the nucleolus of endosperm cells[J]. Plant Biotechnol J, 2011, 9(7): 729-735. [35] Ogo Y, Ozawa K, Ishimaru T, et al. Transgenic rice seed synthesizing diverse flavonoids at high levels: a new platform for flavonoid production with associated health benefits[J]. Plant Biotechnol J, 2013, 11(6): 734–746. [36] Ogo Y, Mori T, Nakabayashi R, et al. Transgenic rice seed expressing flavonoid biosynthetic genes accumulate glycosylated and/or acylated flavonoids in protein, bodies[J]. J Exp Bot, 2016, 67(1): 95-106. [37] 段永波,赵丰兰,倪大虎,等. 水稻胚乳表达药用重组蛋白研究进展[J]. 中国新药杂志,2014(7):787-92. [38] 王淼,王建民,葛云侠,等. 植物反应器在动物疫苗研究中的应用[J]. 湖北农业科学,2012,51(16):3 425-3 426. [39] 金丽鑫,赵凌侠. 植物生物反应器研究现状、瓶颈及策略[J]. 中国生物工程杂志,2009,29(5):104-110. [40] 陈金梅,姜路壹,洪治. 植物生物反应器制药的现状及展望[J]. 生物技术通报,2015(10):1-7.
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