专论与研究

富含叶酸水稻研究进展

展开
  • 1余姚市种子管理站,浙江 余姚 315400;2 浙江大学农业生物技术学院,杭州 310058

网络出版日期: 2017-11-20

基金资助

浙江省水稻育种(2016C2050-6)

Progress on High Folate Content Rice

Expand

Online published: 2017-11-20

摘要

叶酸缺乏是世界性的公共健康问题,严重影响人类健康。水稻是世界第一大主粮,也是我国大部分人日常能量摄入的主要来源。但是水稻籽粒中叶酸含量极低,因此,通过提高水稻的叶酸含量将有助于解决我国以及全球许多以水稻为主粮的国家和地区的叶酸缺乏问题。本文介绍了叶酸的结构、在生物中的生理功能及叶酸缺乏带来的影响,阐述了叶酸在植物体内生物合成的途径,以及目前水稻叶酸强化的研究进展。

本文引用格式

韩娟英1,何曦2,蒋宙蕾2,梅沙2,张宁2*,吴殿星2 . 富含叶酸水稻研究进展[J]. 中国稻米, 2017 , 23(6) : 7 -12 . DOI: 10.3969/j.issn.1006-8082.2017.06.002

Abstract

Folates deficiency is a global public health problem, has profound effects on human health. Rice is the most important staple crops in the world, and provides most population energy intake in China. Since rice seeds contain very little folates, enhancing folates content in rice would be a cost-effective way to solve folates deficiency in China and some countries and regions where the staple crop is rice. This review introduced the structure and physiological functions of folates, and the influences of folates deficiency. The biosynthetic pathway in plant and progress in folates-biofortification rice were also reported.

参考文献

[1] Storozhenko S, De Brouwer V, Volckaert M, et al. Folate fortification of rice by metabolic engineering[J]. Nat Biotechnol, 2007, 25: 1 277-1 279. [2] Kam K, Arcot J, Adesina AA. Folic acid fortification of parboiled rice: Multifactorial analysis and kineticinvestigation[J]. J Food Eng, 2012, 108: 238-243. [3] Daly LE, Kirke PN, Molloy A, et al. Folate levels and neural tube defects[J]. JAMA, 1995, 274: 1 698-1 702. [4] Ma J, Stampfer MJ, Giovannucci E, et al. Methylenetetrahydrofolatereductase polymorphism, dietary interactions, and risk of colorectal cancer[J]. Cancer Res, 1997, 57: 1 098-1 102. [5] Stover PJ. Physiology of folate and vitamin B12 in health and disease[J]. Nutr Rev, 2004, 62: S3-S12. [6] Wang H, Odegaard A, Thyagarajan B, et al. Blood Folate is associated with asymptomatic or partially symptomatic Alzheimer's disease in the Nun study[J]. J Alzheimer Dis, 2012, 28: 637-645. [7] Daly S, Mills JL, Molloy AM, et al. Minimum effective dose of folic acid for food fortification to prevent neural-tube defects[J]. The Lancet, 1997, 350: 1 666-1 669. [8] Scott J, Kirke P, Molloy A, et al. The role of folate in the prevention of neural-tube defects[J]. Proc Nutr Soc, 1994, 53: 631. [9] De Vriese AS, Blom HJ, Heil SG, et al. Endothelium-derived hyperpolarizing factor–mediated renal vasodilatory response is impaired during acute and chronic hyperhomocysteinemia[J]. Circulation, 2004, 109: 2 331-2 336. [10] De Wals P, Tairou F, Van Allen MI, et al. Reduction in neural-tube defects after folic acid fortification in Canada[J]. N Engl J Med, 2007, 357: 135-142. [11] 张永军. 叶酸能够降低患阿尔茨海默病的危险[J]. 中国保健食品,2006(3): 16. [12] Li Z, Ren A, Liu J, et al. Maternal flu or fever, medication use, and neural tube defects: A population - based case - control study in Northern China[J]. Birth Defects Res A Clin Mol Teratol, 2007,79: 295-300. [13] De Steur H, Gellynck X, Storozhenko S, et al. Health impact in China of folate-biofortifiedrice[J]. Nat Biotechnol, 2010, 28: 554-556. [14] Williams LJ, Mai CT, Edmonds LD, et al. Prevalence of spina bifida and anencephaly during the transition to mandatory folic acid fortification in the United States[J]. Teratology, 2002, 66: 33-39. [15] Hertrampf E, Cortés F. Folic acid fortification of wheat flour: Chile[J]. Nutr Rev, 2004, 62: S44-S48. [16] De Wals P, Tairou F, Van Allen MI, et al. Reduction in neural-tube defects after folic acid fortification in Canada[J]. N Eng J Med, 2007, 357: 135-142. [17] Bekaert S, Storozhenko S, Mehrshahi P, et al. Folatebiofortification in food plants[J]. Trend Plant Sci, 2008, 13: 28-35. [18] Hanson AD, Gregory III JF. Folate biosynthesis, turnover, and transport in plants[J]. Annu Rev Plant Biol, 2011, 62: 105-125. [19] Storozhenko S, De Brouwer V, Volckaert M, et al. Folate fortification of rice by metabolic engineering[J]. Nat Biotechnol, 2007, 25: 1 277-1 279. [20] Brouwer VD, Storozhenko S, Van De Steene JC, et al. Optimisation and validation of a liquid chromatography-tandem mass spectrometry method for folates in rice[J]. J Chromatogr A, 2008, 1215:125-32. [21] Blancquaert D, Storozhenko S, Loizeau K. Folates and folic acid: from fundamental research toward sustainable health[J]. Crit Rev Plant Sci, 2010, 29(3): 14-35. [22] Dong W, Cheng Z, Wang X, et al. Determination of folate content in rice germplasm (Oryza sativa L.) using tri-enzyme extraction and microbiological assays[J]. Int J Food Sci Nutr, 2011, 62: 537-543. [23] Hanson AD, Gregory III JF. Synthesis and turnover of folates in plants[J]. Curr Opin Plant Biol, 2002, 5: 244-249. [24] de la Garza RD, Quinlivan EP, et al. Folate biofortification in tomatoes by engineering the pteridine branch of folatesynthesis[J]. Proc Nat Acad Sci USA, 2004, 101: 13 720-13 725. [25] Goyer A, Collakova E, de la Garza RD, et al. 5-Formyltetrahydrofolate is an inhibitory but well tolerated metabolite in Arabidopsis leaves[J]. J Biol Chem, 2005, 280: 26 137-26 142. [26] Bekaert S, Storozhenko S, Mehrshahi P, et al. Folate biofortification in food plants[J]. Trends Plant Sci, 2007, 13: 28-35. [27] Gillies SA, McIntosh SR, Henry RJ. A cereal crop with enhanced folate: Rice transgenic for wheat HPPK/DHPS[J]. Aust Cereal Chem Conference, 2008. [28] Naqvi S, Zhu C, Farre G, et al. Transgenic multivitamin corn through biofortification of endosperm with three vitamins representing three distinct metabolic pathways[J]. Proc Nat Acad Sci USA, 2009, 106: 7 762-7 767. [29] Nunes AC, Kalkmann DC, Aragao FJ. Folate biofortification of lettuce by expression of a codon optimized chicken GTP cyclohydrolase I gene[J]. Transgenic Res, 2009, 18: 661-667. [30] Akhtar TA, Orsomando G, Mehrshahi P, et al. Central role for gamma‐glutamyl hydrolases in plant folate homeostasis[J]. Plant J, 2009, 2010, 64: 256-266. [31] 董薇. 水稻籽粒叶酸含量QTL分析及生物强化[D]. 北京:中国农业科学院,2011. [32] 鹿晔,刘晓宁,姜凌,等. 过表达蝶呤还原酶PTR1基因促进植物叶酸合成的研究[J]. 中国农业科技导报, 2012,14(5):49-56. [33] Blancquaert D, Van Daele J, Storozhenko S, et al. Rice folate enhancement through metabolic engineering has an impact on rice seed metabolism, but does not affect the expression of the endogenous folate biosynthesis genes[J]. Plant Mol Biol, 2013, 83(4): 329-349. [34] Henderson G B. Folate-binding proteins[J]. Annu Rev Nutr, 1990, 10(1): 319-335. [35] Jones M L, Nixon P F. Tetrahydrofolates are greatly stabilized by binding to bovine milk folate-binding protein[J]. J Nutr, 2002, 132: 2 690-2 694. [36] Goto F, Yoshihara T, Shigemoto N. Iron fortification of rice seed by the soybean ferritin gene[J]. Nat Biotechnol, 1999, 17(3): 282-286.
文章导航

/

浙ICP备05004719号-16
公安备案号:33010302003356
版权所有 © 《中国稻米》编辑部
地址:浙江省杭州市富阳区水稻所路28号 邮编:311400 电话:0571-63370271, 63370368 E-mail:zgdm@163.com
本系统由北京玛格泰克科技发展有限公司设计开发