The experiment of thifluzamide controlling rice sheath blight disease was conducted in Tonghua city, Jinlin Province. The result showed that the diseased panicle rate and disease index of thifluzamide treatment obviously lower than the control. There were no obviously diffrence on diseased plant rate and disease index in thifluzamide treatment and Jin. xi. tricyclazole treatment. Thifluzamide is an excellent preparation to control rice sheath blight disease and could be used in rice production.