Increased soil salinization will lead to a decline in water and fertilizer use efficiency in paddy fields, which will have a greater impact on yield of rice with drip irrigation under mulch film. In response to this phenomenon, the changes of pH value and electrical conductivity of paddy soil after applying different dosages of new acid-base balance agent（7.5 kg/hm², 15.0 kg/hm², 22.5 kg/hm²）, and their effects on yield of rice with drip irrigation under mulch film were studied. The results showed that applying new acid-base balance agent could significantly reduce the soil pH value and electrical conductivity, and the improvement effect is best in the 20~30 cm soil layer; it significantly increased the effective panicles of rice with drip irrigation under mulch film to achieve the purpose of increasing yield. Comprehensive consideration of economic benefits, the application dosage of 15.0 kg/hm² was appropriate.