The effects of nitrogen fertilizer amount and planting density on the growth and yield traits of japonica hybrid rice variety Liaoyou 5206 were studied by using a split zone design, providing a basis for high-yield and high-efficiency cultivation of northern japonica rice. The results showed that with the increase of nitrogen fertilizer amount, the tiller number, dry matter weight at heading stage, SPAD value at jointing stage, plant height and panicle length of rice increased significantly, while the effective panicles, grains per panicle and yield increased but not significant. With the increase of planting density, the tiller number, dry matter weight and panicle number increased significantly; the SPAD value at filling stage, plant height, panicle length and grains per panicle decreased significantly; the SPAD value at heading stage, seed setting rate and output increased first and then decreased. There was no significant interaction effect between nitrogen fertilizer and planting density on most traits such as yield. The best combination of nitrogen fertilizer amount and planting density for high yield was 240 kg/hm² to 167,000 clumps/hm².