Field test results showed that the combination of “propiconazole azoxystrobin + natural chelated boron calcium” has a better control effect on the comprehensive diseases in the late stage of rice and yield increase. After the continuous use of 19% propiconazole azoxystrobin SE 50 mL/667 m² + natural chelated boron calcium 50 mL/667 m² at the end of tillering and mid booting stage of rice, the control effects on rice blast and rice smut were as high as 95.1% and 97.8%. It was significantly better than the treatment of 75% oximeximab · tebuconazole WG 10 g/667 m² and 32.5% benzoxystrobin SC 30 mL/667 m², And the safety is good. The effect of health care and production increase is very obvious. It has a good application prospect in rice production.