Dry direct seeding and drip irrigation cultivation system with mulching film for rice is a high-efficiency water-saving agricultural system, which realizes the integrated operation of water supply and fertilization, and has high utilization prospects in water-deficient area. 100 drought and salt-tolerant japonica rice varieties were selected and studied for the application effect of this system in high-salt and low-yield fields in the Huang-Huai-Hai Plain in the experiment. The results showed that, there were 15 varieties with seedling survival rate greater than 80.0%, 12 varieties with a tiller number more than 11.0, 10 varieties with a plant height taller than 80.0 cm, 3 varieties with theoretical yield more than 400.0 kg/667 m². At the same time, it was found that this system could reduce the salinity of the soil from 0.7% to 0.2%, greatly reducing the impact of salt stress on rice growth from measurement of the soil salinity of under the film in each growth period of rice. Therefore, this system not only can applly in dry direct seeding for rice in Huang-Huai-Hai Plain, but also provides a new solution for the optimizing of local high- salinity and low-yield fields.