Taking Jihong 6 as the test variety, and setting two fertilization modes (cold-tolerant fertilization, high-yield fertilization) and five transplanting densities, we screened the optimal and sub-optimal fertilizer density combinations to guide the wet cultivation of rice with film mulching in the northeast japonica rice area. The results showed that under the condition of cold-tolerant fertilization, due to the fewer amount of fertilizer and higher proportion of application in early stage, the growth rate of biomass and leaf area index in the early stage was faster, and the lodging rate in the mature stage was lower, reflecting a better effect of stabilizing yield. Under the condition of high-yield fertilization, the fertilizer supply in the later period was more sufficient, and the highest yield could reach 705.8 kg/667 m², which reflected a better high-yield effect. In conclusion, the optimal and sub-optimal combination under the condition of wet cultivation with film mulching were“high-yield fertilization + transplanting density of 30 cm×17 cm” and“cold-tolerant fertilization + transplanting density of 30 cm×13 cm”, respectively, the former suitable to the plain area where accumulated temperature is sufficient, the latter suitable to the eastern mountainous area where low cold damage occur frequently.