Guangdong is a strong economy and a large population province. Ensuring food security plays an important role in promoting high-quality development of the social economy. From our survey and statistical data analysis, we discovered several problems in the grain production of Guangdong Province: low self-sufficiency of grain supply, reduction in planting area and yield level, uneven development in various cities, low economic benefit and labor force aging. These problems pose a serious threat to Guangdong’s food security and high-quality development of agriculture. Three strategies for improving Guangdong's grain production are suggested. Firstly, a province-level strategy for industrial upgrading program in grain production should be developed and a comprehensive management department for grain production should be established. Development goals and implementation should be planned and deployed on a basis of whole industrial chain. Secondly, the capacity in major production areas should be further consolidated and strengthened, and the potential gap in other backward areas be filled. Grain production, with rice in particular, should be prioritized in agriculture. The rice planting area should be stabilized and the planting area of all grain crops be increased. The grain production in prefectures with lower yielding level should be prioritized and enhanced. Thirdly, precise policies should formulated and implemented to achieve coordination between the government’s requirement for food security and farmers' demand for benefits, including harvesting more grains in the fields with improved land use, enhancing grain yield with advanced technology, implementing multiple-measure policy for balanced production, prizing farmers with reasonable subsidies and supporting new-type agricultural entities.