Cadmium(Cd) is an important heavy metal that endangers food security. In order to reduce the contents of Cd in rice grains, preventing rice from absorbing and transporting Cd is of great significance. This study took the high-quality indica rice variety Meixiangzhan 2, which had the largest planting area in South China, as the experimental material. Four treatments were set up: healthy soil + spraying water(T1), cadmium contaminated soil + spraying water(T2), cadmium contaminated soil+ spraying low concentration cadmium inhibitor(800-fold liquid) (T3), and cadmium contaminated soil+ spraying high concentration cadmium inhibitor (300-fold liquid)(T4). The effects of spraying different concentrations of cadmium inhibitor on rice yield, photosynthesis, and cadmium absorption were explored. The results showed that spraying cadmium inhibitors could significantly increase rice yield and biomass. Compared with T2 treatment, T3 and T4 treatments increased rice yield by 81.70% and 48.57%, respectively, and increased rice biomass by 53.14% and 24.32%, respectively. Net photosynthetic rate, stomatal conductance, intercellular CO₂ concentration, and transpiration rate increased by 9.72%, 42.76%, 7.30%, and 17.05%, respectively, in T3 treatment, but decreased no significantly in T4 treatment, compared with T2 treatment. There was no significant difference in Cd absorption between all parts of T3 treatment and T2 treatment, among them, the Cd contents in plump grains reduced by 33.11%, but the proportion of grain Cd in the total Cd absorption significantly decreased by 31.77%. This indicated that spraying 800-fold liquid of cadmium inhibitor on rice leaves could enhance photosynthesis, increase biomass, reduce Cd transport to grains, and increase grain yield.