Donggang City is a core production area for high-quality rice in China’s Yellow Sea rice-growing region. The rice-planting area remains stable at around 43,000 hectares, with an annual rice yield of approximately 350,000 tons. In recent years, the growth in rice yield per unit area in Donggang City has stagnated, and efforts to increase the yield per unit area have encountered bottlenecks. From the perspective of achieving large-scale yield enhancement on a county-wide basis, this paper delves into the pathways for improving rice yield per unit area: optimizing the variety structure by breeding rice varieties with “high yield+high quality+multiple resistances”; intensifying policy support, conducting technological research, and vigorously promoting factory-based seedling cultivation; constructing a pest and disease control system featuring “precise monitoring and early warning, green control technologies, and professional operation services”; and promoting land circulation to drive large-scale and standardized production. This paper aims to explore a synergistic development pathway integrating “greenness, high yield, high quality, and industrialization”, providing solid scientific and technological support for enhancing rice supply security capabilities.